发给老马备查:! |' H9 y7 F" b: y
滴水察海(69304838) 15:23:235 K+ | w3 s! H5 D/ Z0 m/ ]+ M; p
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱& l" r/ D1 G0 [: w
吉非替尼和S-1连用的依据
6 u: q, ]3 x0 H. B, l2 R: l+ l* A wGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.. h. y8 Q) y8 ? r( s6 E0 h
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
5 Y2 }1 @7 e2 y3 K- q% Z这样是不是推理出,耐药后,可以用S-1和培美了?2 c" l- e- @1 _9 t8 x) `8 H" M
结论:* R+ o- [& |( U# K2 q& t/ y
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |